Integrative GWAS and Mendelian Randomization Analysis Identifies IREB2 and CD27+ Memory B Cells as Core Drivers of COPD to Lung Cancer Progression

ABSTRACT Chronic obstructive pulmonary disease (COPD) associates with increased lung cancer incidence and shares genetic susceptibility, yet its independent causal role and driver mechanisms are poorly understood. We integrated data from the National Health and Nutrition Examination Survey (NHANES)...

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Huvudupphov:	Erkang Yi, Qingyang Li, Wenqian Wu, Chengshu Xie, Hairong Wang, Erping Long, Fan Wu, Xuanyi Lu, Yu Liu, Ruiting Sun, Xinqing Lin, Xiaohong Xie, Yumin Zhou, Chengzhi Zhou, Pixin Ran
Materialtyp:	Artigo
Språk:	Inglês
Utgiven:	Wiley 2025-12-01
Serie:	MedComm
Ämnen:	chronic obstructive pulmonary disease GWAS IREB2 lung cancer mendelian randomization
Länkar:	https://doi.org/10.1002/mco2.70473
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