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Sensitive and reliable detection of Kit point mutation Asp 816 to Val in pathological material

<p>Abstract</p> <p>Background</p> <p>Human mastocytosis is a heterogenous disorder which is linked to a gain-of-function mutation in the kinase domain of the receptor tyrosine kinase Kit. This D816V mutation leads to constitutive activation and phosphorylation of Kit with proliferative disorders of...

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Váldodahkkit: Feller Alfred C, Didlaukat Sabine, Kähler Christian, Merz Hartmut
Materiálatiipa: Artigo
Giella:Inglês
Almmustuhtton: BMC 2007-09-01
Ráidu:Diagnostic Pathology
Liŋkkat:http://www.diagnosticpathology.org/content/2/1/37
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