Localized Delivery of the mRNAs Encoding CD47 Inhibitor and Interleukins 12, 15, and 21 Elicits Robust Antitumor Immunity

Abstract CD47 inhibitors have emerged as promising candidates in cancer immunotherapy by activating macrophage phagocytosis through CD47/SIRPα signal blockade and enhancing dendritic cell antigen presentation. However, their clinical efficacy remains limited and is accompanied by severe side effects...

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Detalhes bibliográficos

Principais autores:	Tao Jiang, Shuaiyang Jing, Haojun Li, Bao Xiao, Jiahui Jin, Xiu Sun, Juan Wang, Jing Liang, Tongze Cai, Huili Hu, Meilan Wei, Xuanrui Zhong, Yang Ji, Peng George Wang, Jianlong Zhou
Formato:	Artigo
Idioma:	Inglês
Publicado em:	Wiley 2025-10-01
Colecção:	Advanced Science
Assuntos:	CD47 inhibitor cytokine immunotherapy lipid nanoparticle mRNA therapeutics
Acesso em linha:	https://doi.org/10.1002/advs.202417205
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