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Oncolytic vaccinia virus armed with anti-CD47 nanobody elicit potent antitumor effects on multiple tumor models via enhancing innate and adoptive immunity

Objective Targeting CD47 for cancer immunotherapy has been studied in many clinical trials for the treatment of patients with advanced tumors. However, this therapeutic approach is often hampered by on-target side effects, physical barriers, and immunosuppressive tumor microenvironment (TME).Methods...

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I tiakina i:
Ngā taipitopito rārangi puna kōrero
Ngā kaituhi matua: Jie Chen, Liu Yang, Mengyuan Li, Qian Ye, Shibing Wang, Zengpeng Li, Wenbin Qian
Hōputu: Artigo
Reo:Inglês
I whakaputaina: BMJ Publishing Group 2024-12-01
Rangatū:Journal for ImmunoTherapy of Cancer
Urunga tuihono:https://jitc.bmj.com/content/12/12/e009473.full
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