Localized Delivery of the mRNAs Encoding CD47 Inhibitor and Interleukins 12, 15, and 21 Elicits Robust Antitumor Immunity

Abstract CD47 inhibitors have emerged as promising candidates in cancer immunotherapy by activating macrophage phagocytosis through CD47/SIRPα signal blockade and enhancing dendritic cell antigen presentation. However, their clinical efficacy remains limited and is accompanied by severe side effects...

תיאור מלא

מידע ביבליוגרפי

Principais autores:	Tao Jiang, Shuaiyang Jing, Haojun Li, Bao Xiao, Jiahui Jin, Xiu Sun, Juan Wang, Jing Liang, Tongze Cai, Huili Hu, Meilan Wei, Xuanrui Zhong, Yang Ji, Peng George Wang, Jianlong Zhou
פורמט:	Artigo
שפה:	Inglês
יצא לאור:	Wiley 2025-10-01
סדרה:	Advanced Science
נושאים:	CD47 inhibitor cytokine immunotherapy lipid nanoparticle mRNA therapeutics
גישה מקוונת:	https://doi.org/10.1002/advs.202417205
תגים:	הוספת תג אין תגיות, היה/י הראשונ/ה לתייג את הרשומה!