Cerebral Microvascular Injury Induced by Lag3‐Dependent α‐Synuclein Fibril Endocytosis Exacerbates Cognitive Impairment in a Mouse Model of α‐Synucleinopathies

Abstract The pathological accumulation of α‐synuclein (α‐Syn) and the transmission of misfolded α‐Syn underlie α‐synucleinopathies. Increased plasma α‐Syn levels are associated with cognitive impairment in Parkinson's disease, multiple system atrophy, and dementia with Lewy bodies, but it is still u...

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Detalhes bibliográficos

Principais autores:	Qingxi Zhang, Qingrui Duan, Yuyuan Gao, Peikun He, Rui Huang, Haifeng Huang, Yanyi Li, Guixian Ma, Yuhu Zhang, Kun Nie, Lijuan Wang
Formato:	Artigo
Idioma:	Inglês
Publicado em:	Wiley 2023-09-01
coleção:	Advanced Science
Assuntos:	α‐Syn preformed fibril(s) (PFFs) α‐synucleinopathies cerebral microvascular injury cognitive impairment lymphocyte‐activation gene 3 (Lag3)
Acesso em linha:	https://doi.org/10.1002/advs.202301903
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