Cerebral Microvascular Injury Induced by Lag3‐Dependent α‐Synuclein Fibril Endocytosis Exacerbates Cognitive Impairment in a Mouse Model of α‐Synucleinopathies

Abstract The pathological accumulation of α‐synuclein (α‐Syn) and the transmission of misfolded α‐Syn underlie α‐synucleinopathies. Increased plasma α‐Syn levels are associated with cognitive impairment in Parkinson's disease, multiple system atrophy, and dementia with Lewy bodies, but it is still u...

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Autores principales:	Qingxi Zhang, Qingrui Duan, Yuyuan Gao, Peikun He, Rui Huang, Haifeng Huang, Yanyi Li, Guixian Ma, Yuhu Zhang, Kun Nie, Lijuan Wang
Formato:	Artigo
Lenguaje:	Inglês
Publicado:	Wiley 2023-09-01
Colección:	Advanced Science
Materias:	α‐Syn preformed fibril(s) (PFFs) α‐synucleinopathies cerebral microvascular injury cognitive impairment lymphocyte‐activation gene 3 (Lag3)
Acceso en línea:	https://doi.org/10.1002/advs.202301903
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