Cerebral Microvascular Injury Induced by Lag3‐Dependent α‐Synuclein Fibril Endocytosis Exacerbates Cognitive Impairment in a Mouse Model of α‐Synucleinopathies

Abstract The pathological accumulation of α‐synuclein (α‐Syn) and the transmission of misfolded α‐Syn underlie α‐synucleinopathies. Increased plasma α‐Syn levels are associated with cognitive impairment in Parkinson's disease, multiple system atrophy, and dementia with Lewy bodies, but it is still u...

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Autors principals:	Qingxi Zhang, Qingrui Duan, Yuyuan Gao, Peikun He, Rui Huang, Haifeng Huang, Yanyi Li, Guixian Ma, Yuhu Zhang, Kun Nie, Lijuan Wang
Format:	Artigo
Idioma:	Inglês
Publicat:	Wiley 2023-09-01
Col·lecció:	Advanced Science
Matèries:	α‐Syn preformed fibril(s) (PFFs) α‐synucleinopathies cerebral microvascular injury cognitive impairment lymphocyte‐activation gene 3 (Lag3)
Accés en línia:	https://doi.org/10.1002/advs.202301903
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