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Development of a Novel Method to Detect AAV Vector Integration

AAV integration has become an important safety consideration in gene therapy. However, accurately determining integration sites remains challenging due to biases introduced by library preparation methods, sequencing technologies, and bioinformatic pipelines. In this study, we developed a PCR-free am...

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Uloženo v:
Hlavní autoři: Junping Zhang, Thao Thi Dang, Tsai-Yu Lin, Xiangping Yu, Danilo Pellin, Jiahe Tian, Olga Simmons, Emma Kou, Kenneth Cornetta, Weidong Xiao
Médium: Artigo
Jazyk:Inglês
Vydáno: MDPI AG 2026-03-01
Edice:Viruses
Témata:
AAV vector
AAV integration
CRISPR-Cas9
nanopore
sequencing
hybridization capture
On-line přístup:https://www.mdpi.com/1999-4915/18/3/315
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