Querying Recombination Junctions of Replication-Competent Adeno-Associated Viruses in Gene Therapy Vector Preparations with Single Molecule, Real-Time Sequencing

Clinical-grade preparations of adeno-associated virus (AAV) vectors used for gene therapy typically undergo a series of diagnostics to determine titer, purity, homogeneity, and the presence of DNA contaminants. One type of contaminant that remains poorly investigated is replication-competent (rc)AAV...

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主要な著者:	Mitchell Yip, Jing Chen, Yan Zhi, Ngoc Tam Tran, Suk Namkung, Eric Pastor, Guangping Gao, Phillip W. L. Tai
フォーマット:	Artigo
言語:	Inglês
出版事項:	MDPI AG 2023-05-01
シリーズ:	Viruses
主題:	adeno-associated virus replication-competent AAV single molecule real-time sequencing AAV-genome population sequencing
オンライン･アクセス:	https://www.mdpi.com/1999-4915/15/6/1228
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