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The Expression of Cellular Prion Protein, PrPC, Favors pTau Propagation and Blocks NMDAR Signaling in Primary Cortical Neurons

Background: The N-methyl-D-aspartate receptor (NMDAR) is a target in current treatments for Alzheimer’s disease (AD). The human prion protein (PrPC) has an important role in the pathophysiology of AD. We hypothesized that PrPC modulates NMDA signaling, thus being a process associated with Alzheimer’...

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Principais autores: Rafael Rivas-Santisteban, Iu Raïch, David Aguinaga, Carlos A. Saura, Rafael Franco, Gemma Navarro
Format: Artigo
Sprog:Inglês
Udgivet: MDPI AG 2023-01-01
Serier:Cells
Fag:
Alzheimer’s disease
NMDA
prion protein
Tau protein
pTau protein
axonal transport
Online adgang:https://www.mdpi.com/2073-4409/12/2/283
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