The Expression of Cellular Prion Protein, PrPC, Favors pTau Propagation and Blocks NMDAR Signaling in Primary Cortical Neurons

Background: The N-methyl-D-aspartate receptor (NMDAR) is a target in current treatments for Alzheimer’s disease (AD). The human prion protein (PrPC) has an important role in the pathophysiology of AD. We hypothesized that PrPC modulates NMDA signaling, thus being a process associated with Alzheimer’...

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Autors principals:	Rafael Rivas-Santisteban, Iu Raïch, David Aguinaga, Carlos A. Saura, Rafael Franco, Gemma Navarro
Format:	Artigo
Idioma:	Inglês
Publicat:	MDPI AG 2023-01-01
Col·lecció:	Cells
Matèries:	Alzheimer’s disease NMDA prion protein Tau protein pTau protein axonal transport
Accés en línia:	https://www.mdpi.com/2073-4409/12/2/283
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