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ER Ca2+ overload activates the IRE1α signaling and promotes cell survival

Abstract Background Maintaining homeostasis of Ca2+ stores in the endoplasmic reticulum (ER) is crucial for proper Ca2+ signaling and key cellular functions. Although Ca2+ depletion has been known to cause ER stress which in turn activates the unfolded protein response (UPR), how UPR sensors/transdu...

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Principais autores: Song Zhao, Haiping Feng, Dongfang Jiang, Keyan Yang, Si-Tong Wang, Yu-Xin Zhang, Yun Wang, Hongmei Liu, Caixia Guo, Tie-Shan Tang
Format: Artigo
Sprog:Inglês
Udgivet: BMC 2023-07-01
Serier:Cell & Bioscience
Fag:
ER Ca2+ overload
TMCO1
ER stress
IRE1α
Online adgang:https://doi.org/10.1186/s13578-023-01062-y
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