Adenoviral TMBIM6 vector attenuates ER-stress-induced apoptosis in a neonatal hypoxic-ischemic rat model

Endoplasmic reticulum (ER) stress is a major pathology encountered after hypoxic-ischemic (HI) injury. Accumulation of unfolded proteins triggers the unfolded protein response (UPR), resulting in the activation of pro-apoptotic cascades that lead to cell death. Here, we identified Bax inhibitor 1 (B...

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Detalhes bibliográficos

Principais autores:	Desislava Doycheva, Ningbo Xu, Harpreet Kaur, Jay Malaguit, Devin William McBride, Jiping Tang, John H. Zhang
Formato:	Artigo
Idioma:	Inglês
Publicado em:	The Company of Biologists 2019-11-01
coleção:	Disease Models & Mechanisms
Assuntos:	neonatal hypoxia ischemia bax inhibitor 1 tmbim6 er stress apoptosis
Acesso em linha:	http://dmm.biologists.org/content/12/11/dmm040352
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