Mitochondrial glutathione transporter SLC25A40 regulates macrophage cytokine production

Abstract Mitochondrial glutathione (mtGSH) supports iron-sulfur cluster (ISC) stability in the electron transport chain (ETC). Here we have investigated the role of the mtGSH transporter SLC25A40 in macrophage activation. SLC25A40 is present in both murine and human macrophages and its expression wa...

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Үндсэн зохиолчид:	Maureen Yin, Eva M. Palsson-McDermott, Órlaith C. Henry, Ziqian Ge, Juliana E. Toller-Kawahisa, Yukun Min, Anne F. McGettrick, Adam L. Gordon, Stella B. Heffernan, Laura Marrone, Bryan P. Marzullo, Katherine L. Eales, Sally A. Clayton, Daniel A. Tennant, Richard K. Porter, Luke A. J. O’Neill
Формат:	Artigo
Хэл сонгох:	Inglês
Хэвлэсэн:	Nature Portfolio 2025-12-01
Цуврал:	Scientific Reports
Нөхцлүүд:	Mitochondria Macrophage immunometabolism Glutathione (GSH) Electron transport chain (ETC) Cytokine SLC25A39/40
Онлайн хандалт:	https://doi.org/10.1038/s41598-025-30333-6
Шошгууд:	Шошго нэмэх Шошго байхгүй, Энэхүү баримтыг шошголох эхний хүн болох!