Mitochondrial glutathione transporter SLC25A40 regulates macrophage cytokine production

Abstract Mitochondrial glutathione (mtGSH) supports iron-sulfur cluster (ISC) stability in the electron transport chain (ETC). Here we have investigated the role of the mtGSH transporter SLC25A40 in macrophage activation. SLC25A40 is present in both murine and human macrophages and its expression wa...

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主要な著者:	Maureen Yin, Eva M. Palsson-McDermott, Órlaith C. Henry, Ziqian Ge, Juliana E. Toller-Kawahisa, Yukun Min, Anne F. McGettrick, Adam L. Gordon, Stella B. Heffernan, Laura Marrone, Bryan P. Marzullo, Katherine L. Eales, Sally A. Clayton, Daniel A. Tennant, Richard K. Porter, Luke A. J. O’Neill
フォーマット:	Artigo
言語:	Inglês
出版事項:	Nature Portfolio 2025-12-01
シリーズ:	Scientific Reports
主題:	Mitochondria Macrophage immunometabolism Glutathione (GSH) Electron transport chain (ETC) Cytokine SLC25A39/40
オンライン･アクセス:	https://doi.org/10.1038/s41598-025-30333-6
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