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Structural studies of the phosphoribosyltransferase involved in cobamide biosynthesis in methanogenic archaea and cyanobacteria

Abstract Cobamides (Cbas) are coenzymes used by cells across all domains of life, but de novo synthesis is only found in some bacteria and archaea. Five enzymes assemble the nucleotide loop in the alpha phase of the corrin ring. Condensation of the activated ring and nucleobase yields adenosyl-Cba 5...

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Auteurs principaux: Victoria L. Jeter, Anne H. Schwarzwalder, Ivan Rayment, Jorge C. Escalante-Semerena
Format: Artigo
Langue:Inglês
Publié: Nature Portfolio 2022-10-01
Collection:Scientific Reports
Accès en ligne:https://doi.org/10.1038/s41598-022-21765-5
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