The decrease in uroporphyrinogen decarboxylase activity induced by ethanol predisposes rats to the development of porphyria and accelerates xenobiotic-triggered porphyria, regardless of hepatic damage

We evaluated the porphyrinogenic ability of ethanol (20% in drinking water) per se, its effect on the development of sporadic porphyria cutanea tarda induced by hexachlorobenzene in female Wistar rats (170-190 g, N = 8/group), and the relationship with hepatic damage. Twenty-five percent of the anim...

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Bibliografische Detailangaben

Hauptverfasser:	M.C. Ríos de Molina, M.B. Mazzetti, M. Galigniana, C. Aldonatti, J.M. Tomio, L.C. San Martín de Viale
Format:	Artigo
Sprache:	Inglês
Veröffentlicht:	Associação Brasileira de Divulgação Científica 2002-11-01
Schriftenreihe:	Brazilian Journal of Medical and Biological Research
Schlagworte:	Alcoholism Ethanol Heme metabolic pathway Hepatic damage Hexachlorobenzene Porphyria cutanea tarda
Online-Zugang:	http://www.scielo.br/scielo.php?script=sci_arttext&pid=S0100-879X2002001100004
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