Crystal structure of ricin toxin A chain complexed with a highly potent pterin-based small-molecular inhibitor

Ricin toxin A chain (RTA), from Ricinus communis, is a deadly protein that inactivates ribosomes by degrading an adenine residue at position 4324 in 28S rRNA. Recently, we have demonstrated that pterin-7-carboxamides with peptide pendants were potent RTA inhibitors. Among these, N-(pterin-7-carbonyl...

Полное описание

Библиографические подробности

Главные авторы:	Masaru Goto, Natsumi Sakamoto, Shoko Higashi, Rena Kawata, Kazuki Nagatsu, Ryota Saito
Формат:	Artigo
Язык:	Inglês
Опубликовано:	Taylor & Francis Group 2023-12-01
Серии:	Journal of Enzyme Inhibition and Medicinal Chemistry
Предметы:	Ricin toxin A chain ricin toxin A chain inhibitor pterin-7-carboxamide X-ray crystallography
Online-ссылка:	https://www.tandfonline.com/doi/10.1080/14756366.2023.2219038
Метки:	Добавить метку Нет меток, Требуется 1-ая метка записи!