Crystal structure of ricin toxin A chain complexed with a highly potent pterin-based small-molecular inhibitor
Ricin toxin A chain (RTA), from Ricinus communis, is a deadly protein that inactivates ribosomes by degrading an adenine residue at position 4324 in 28S rRNA. Recently, we have demonstrated that pterin-7-carboxamides with peptide pendants were potent RTA inhibitors. Among these, N-(pterin-7-carbonyl...
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| Autori principali: | , , , , , |
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| Natura: | Artigo |
| Lingua: | Inglês |
| Pubblicazione: |
Taylor & Francis Group
2023-12-01
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| Serie: | Journal of Enzyme Inhibition and Medicinal Chemistry |
| Soggetti: | |
| Accesso online: | https://www.tandfonline.com/doi/10.1080/14756366.2023.2219038 |
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