Crystal structure of ricin toxin A chain complexed with a highly potent pterin-based small-molecular inhibitor

Ricin toxin A chain (RTA), from Ricinus communis, is a deadly protein that inactivates ribosomes by degrading an adenine residue at position 4324 in 28S rRNA. Recently, we have demonstrated that pterin-7-carboxamides with peptide pendants were potent RTA inhibitors. Among these, N-(pterin-7-carbonyl...

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Autors principals:	Masaru Goto, Natsumi Sakamoto, Shoko Higashi, Rena Kawata, Kazuki Nagatsu, Ryota Saito
Format:	Artigo
Idioma:	Inglês
Publicat:	Taylor & Francis Group 2023-12-01
Col·lecció:	Journal of Enzyme Inhibition and Medicinal Chemistry
Matèries:	Ricin toxin A chain ricin toxin A chain inhibitor pterin-7-carboxamide X-ray crystallography
Accés en línia:	https://www.tandfonline.com/doi/10.1080/14756366.2023.2219038
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