Celastrol and Triptolide Suppress Stemness in Triple Negative Breast Cancer: Notch as a Therapeutic Target for Stem Cells

Triple negative breast cancer (TNBC) is observed in ~15% of breast cancers and results in poor survival and increased distant metastases. Within the tumor are present a small portion of cancer stem cells that drive tumorigenesis and metastasis. In this study, we aimed to elucidate whether the two na...

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Detalhes bibliográficos

Principais autores:	Prabhu Ramamoorthy, Prasad Dandawate, Roy A. Jensen, Shrikant Anant
Formato:	Artigo
Idioma:	Inglês
Publicado em:	MDPI AG 2021-04-01
coleção:	Biomedicines
Assuntos:	mammospheres DCLK1 ALDH1 γ-secretase presenilin nicastrin
Acesso em linha:	https://www.mdpi.com/2227-9059/9/5/482
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