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Celastrol and Triptolide Suppress Stemness in Triple Negative Breast Cancer: Notch as a Therapeutic Target for Stem Cells

Triple negative breast cancer (TNBC) is observed in ~15% of breast cancers and results in poor survival and increased distant metastases. Within the tumor are present a small portion of cancer stem cells that drive tumorigenesis and metastasis. In this study, we aimed to elucidate whether the two na...

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Principais autores: Prabhu Ramamoorthy, Prasad Dandawate, Roy A. Jensen, Shrikant Anant
Format: Artigo
Sprog:Inglês
Udgivet: MDPI AG 2021-04-01
Serier:Biomedicines
Fag:
mammospheres
DCLK1
ALDH1
γ-secretase
presenilin
nicastrin
Online adgang:https://www.mdpi.com/2227-9059/9/5/482
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