Polymerization of C9 enhances bacterial cell envelope damage and killing by membrane attack complex pores

Complement proteins can form membrane attack complex (MAC) pores that directly kill Gram-negative bacteria. MAC pores assemble by stepwise binding of C5b, C6, C7, C8 and finally C9, which can polymerize into a transmembrane ring of up to 18 C9 monomers. It is still unclear if the assembly of a polym...

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Autores principales:	Dennis J. Doorduijn, Dani A. C. Heesterbeek, Maartje Ruyken, Carla J. C. de Haas, Daphne A. C. Stapels, Piet C. Aerts, Suzan H. M. Rooijakkers, Bart W. Bardoel
Formato:	Artigo
Lenguaje:	Inglês
Publicado:	Public Library of Science (PLoS) 2021-11-01
Colección:	PLoS Pathogens
Acceso en línea:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8604303/?tool=EBI
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