Klebsiella LPS O1-antigen prevents complement-mediated killing by inhibiting C9 polymerization

Abstract The Gram-negative bacterium Klebsiella pneumoniae is an important human pathogen. Its treatment has been complicated by the emergence of multi-drug resistant strains. The human complement system is an important part of our innate immune response that can directly kill Gram-negative bacteria...

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Hlavní autoři:	Frerich M. Masson, Salvör Káradóttir, Sjors P. A. van der Lans, Dennis J. Doorduijn, Carla J. C. de Haas, Suzan H. M. Rooijakkers, Bart W. Bardoel
Médium:	Artigo
Jazyk:	Inglês
Vydáno:	Nature Portfolio 2024-09-01
Edice:	Scientific Reports
On-line přístup:	https://doi.org/10.1038/s41598-024-71487-z
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