Co-culture with fibroblasts in stiff 3D scaffolds increases CD54 and CD140a expression on macrophages

Vascular fibrosis is a major contributor to hypertension and cardiovascular disease and is caused by excessive extracellular matrix deposition and tissue stiffening. Macrophages and fibroblasts are key regulators of this process, yet most studies have relied on non-physiological two-dimensional (2D)...

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主要な著者:	Jennessa WX Ng, Santosh TRB Rao, Emily H. Field, Kaitlyn Ritchie, Mark D. Wright, Nicholas P. Reynolds, Sean W. Cutter, Katrina J. Binger
フォーマット:	Artigo
言語:	Inglês
出版事項:	Frontiers Media S.A. 2026-06-01
シリーズ:	Frontiers in Immunology
主題:	3D culture co-culture macrophage activation myofibroblast vascular fibrosis
オンライン･アクセス:	https://www.frontiersin.org/articles/10.3389/fimmu.2026.1771248/full
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