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Genetic knock-down of HDAC3 does not modify disease-related phenotypes in a mouse model of Huntington's disease.

Huntington's disease (HD) is an autosomal dominant progressive neurodegenerative disorder caused by an expansion of a CAG/polyglutamine repeat for which there are no disease modifying treatments. In recent years, transcriptional dysregulation has emerged as a pathogenic process that appears early in...

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-д хадгалсан:
Номзүйн дэлгэрэнгүй
Үндсэн зохиолчид: Lara Moumné, Ken Campbell, David Howland, Yingbin Ouyang, Gillian P Bates
Формат: Artigo
Хэл сонгох:Inglês
Хэвлэсэн: Public Library of Science (PLoS) 2012-01-01
Цуврал:PLoS ONE
Онлайн хандалт:https://journals.plos.org/plosone/article/file?id=10.1371/journal.pone.0031080&type=printable
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