RNA Interference by Single- and Double-stranded siRNA With a DNA Extension Containing a 3′ Nuclease-resistant Mini-hairpin Structure

Selective gene silencing by RNA interference (RNAi) involves double-stranded small interfering RNA (ds siRNA) composed of single-stranded (ss) guide and passenger RNAs. siRNA is recognized and processed by Ago2 and C3PO, endonucleases of the RNA-induced silencing complex (RISC). RISC cleaves passeng...

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Bibliografische Detailangaben

Hauptverfasser:	Simon J Allison, Jo Milner
Format:	Artigo
Sprache:	Inglês
Veröffentlicht:	Elsevier 2014-01-01
Schriftenreihe:	Molecular Therapy: Nucleic Acids
Schlagworte:	Ago2 C3PO nuclease-resistant DNA mini-hairpin RNAi SIRT1 therapy 3′-DNA/siRNA constructs
Online-Zugang:	http://www.sciencedirect.com/science/article/pii/S2162253116302803
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