Immune Tolerance to Tumor Antigens Occurs in a Specialized Environment of the Spleen

Peripheral tolerance to tumor antigens (Ags) is a major hurdle for antitumor immunity. Draining lymph nodes are considered the privileged sites for Ag presentation to T cells and for the onset of peripheral tolerance. Here, we show that the spleen is fundamentally important for tumor-induced toleran...

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Autors principals:	Stefano Ugel, Elisa Peranzoni, Giacomo Desantis, Mariacristina Chioda, Steffen Walter, Toni Weinschenk, Jordi C. Ochando, Anna Cabrelle, Susanna Mandruzzato, Vincenzo Bronte
Format:	Artigo
Idioma:	Inglês
Publicat:	Elsevier 2012-09-01
Col·lecció:	Cell Reports
Accés en línia:	http://www.sciencedirect.com/science/article/pii/S2211124712002318
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