Immune Tolerance to Tumor Antigens Occurs in a Specialized Environment of the Spleen
Peripheral tolerance to tumor antigens (Ags) is a major hurdle for antitumor immunity. Draining lymph nodes are considered the privileged sites for Ag presentation to T cells and for the onset of peripheral tolerance. Here, we show that the spleen is fundamentally important for tumor-induced toleran...
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| Hauptverfasser: | , , , , , , , , , |
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| Format: | Artigo |
| Sprache: | Inglês |
| Veröffentlicht: |
Elsevier
2012-09-01
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| Schriftenreihe: | Cell Reports |
| Online-Zugang: | http://www.sciencedirect.com/science/article/pii/S2211124712002318 |
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