Effects of islatravir (4′-ethynyl-2-fluoro-2′-deoxyadenosine or EFdA) on renal tubular cells and islatravir's interactions with organic anion transporters

Islatravir (ISL; 4′-ethynyl-2-fluoro-2′-deoxyadenosine or EFdA) is a novel reverse transcriptase translocation inhibitor and has a unique structure and high antiviral activity against wild-type and multidrug resistant HIV strains. In this study, we investigated whether islatravir (ISL) can cause kid...

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Detalhes bibliográficos

Principais autores:	Meika Kaneko, Yoshie Reien, Hanae Morio, Tomoko Fukuuchi, Kiyoko Kaneko, Yuri Hirayama, Hirofumi Hashimoto, Nobuyo Kuwata, Hiroaki Mitsuya, Naohiko Anzai
Formato:	Artigo
Idioma:	Inglês
Publicado em:	Elsevier 2021-06-01
coleção:	Journal of Pharmacological Sciences
Assuntos:	Islatravir Nucleoside reverse transcriptase inhibitors Organic anion transporters Renal tubular cells Kidney damage
Acesso em linha:	http://www.sciencedirect.com/science/article/pii/S1347861321000244
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