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High-Resolution Histological Landscape of AAV DNA Distribution in Cellular Compartments and Tissues following Local and Systemic Injection

Adeno-associated virus (AAV) is one of the most important gene delivery vehicles for in vivo gene therapy. Intramuscular (i.m.) and intravascular (i.v.) injection are commonly used for AAV gene transfer. Unfortunately, the fate of AAV vectors following administration remains unclear at the histologi...

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Principais autores: Junling Zhao, Yongping Yue, Aman Patel, Lakmini Wasala, Jacob F. Karp, Keqing Zhang, Dongsheng Duan, Yi Lai
Formato: Artigo
Idioma:Inglês
Publicado em: Elsevier 2020-09-01
coleção:Molecular Therapy: Methods & Clinical Development
Assuntos:
in situ hybridization
RNAscope
AAV
histology
intramuscular
intravenous
Acesso em linha:http://www.sciencedirect.com/science/article/pii/S2329050120301728
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