Lower expression of neuronal isoform in vulnerable excitatory neurons increases risk in Alzheimer's disease

Background:  Neurons in Alzheimer's disease (AD) experience elevated DNA damage, with DNA repair sites enriched at enhancer regions of genes essential for neuronal survival. Excitatory neurons in the cortical superficial layers expressing CUX2 and RORB (Cux2+/Rorb+), are selectively vulnerable in AD...

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Detalhes bibliográficos

Principais autores:	Rajesh Ranganathan, Siwen Li, Georgy Sapozhnikov, Shoutang Wang, You-Qiang Song
Formato:	Artigo
Idioma:	Inglês
Publicado em:	SAGE Publishing 2025-01-01
coleção:	Journal of Alzheimer's Disease Reports
Acesso em linha:	https://doi.org/10.1177/25424823241296018
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