Stable CDK12 Knock-Out Ovarian Cancer Cells Do Not Show Increased Sensitivity to Cisplatin and PARP Inhibitor Treatment

Cyclin-dependent kinase 12 (CDK12) is a serine/threonine kinase involved in the regulation of RNA polymerase II and in the transcription of a subset of genes involved in the DNA damage response. CDK12 is one of the most mutated genes in ovarian carcinoma. These mutations result in loss-of-function a...

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Autores principales:	Rosaria Chilà, Michela Chiappa, Federica Guffanti, Nicolò Panini, Donatella Conconi, Andrea Rinaldi, Luciano Cascione, Francesco Bertoni, Maddalena Fratelli, Giovanna Damia
Formato:	Artigo
Lenguaje:	Inglês
Publicado:	Frontiers Media S.A. 2022-07-01
Colección:	Frontiers in Oncology
Materias:	CDK12 ovarian carcinoma PARP inhibitor cisplatin DNA damage
Acceso en línea:	https://www.frontiersin.org/articles/10.3389/fonc.2022.903536/full
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