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Local translation controls early reactive changes in perisynaptic astrocyte processes at pre-symptomatic stages of Alzheimer's disease

Early synaptic dysfunction is a hallmark of Alzheimer's disease (AD), yet the astrocytic mechanisms underlying these alterations remain poorly defined. Here, we identify astrocyte perisynaptic processes (PAPs) as subcellular hotspots of early translational dysregulation in AD. Soluble Aβ₁–₄₂ rapidly...

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Asıl Yazarlar: Katia Avila-Gutierrez, María Ángeles Carrillo de Sauvage, Noémie Depret, Marc Oudart, Robin Thompson, Rodrigo Alvear-Perez, Yiannis Poulot-Becq-Giraudon, Esther Kozlowski, Heloïse Monnet, Philippe Mailly, Valentin Garcia, Laurent Jourdren, Alexandre Lucas, Alexis Bemelmans, Helene Hirbec, Carole Escartin, Martine Cohen-Salmon
Materyal Türü: Artigo
Dil:Inglês
Baskı/Yayın Bilgisi: Elsevier 2026-09-01
Seri Bilgileri:Neurobiology of Disease
Konular:
Astrocytes
Astrocyte reactivity
Perisynaptic astrocyte process
Synapse
Inflammation
Glia
Online Erişim:http://www.sciencedirect.com/science/article/pii/S0969996126002731
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