Local translation controls early reactive changes in perisynaptic astrocyte processes at pre-symptomatic stages of Alzheimer's disease

Early synaptic dysfunction is a hallmark of Alzheimer's disease (AD), yet the astrocytic mechanisms underlying these alterations remain poorly defined. Here, we identify astrocyte perisynaptic processes (PAPs) as subcellular hotspots of early translational dysregulation in AD. Soluble Aβ₁–₄₂ rapidly...

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Hauptverfasser:	Katia Avila-Gutierrez, María Ángeles Carrillo de Sauvage, Noémie Depret, Marc Oudart, Robin Thompson, Rodrigo Alvear-Perez, Yiannis Poulot-Becq-Giraudon, Esther Kozlowski, Heloïse Monnet, Philippe Mailly, Valentin Garcia, Laurent Jourdren, Alexandre Lucas, Alexis Bemelmans, Helene Hirbec, Carole Escartin, Martine Cohen-Salmon
Format:	Artigo
Sprache:	Inglês
Veröffentlicht:	Elsevier 2026-09-01
Schriftenreihe:	Neurobiology of Disease
Schlagworte:	Astrocytes Astrocyte reactivity Perisynaptic astrocyte process Synapse Inflammation Glia
Online-Zugang:	http://www.sciencedirect.com/science/article/pii/S0969996126002731
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