Discovery of a Novel and Potent Kir4.1 Inhibitor as a Safe and Rapid‐Onset Antidepressant Agent in Mice

Abstract Major depressive disorder is a serious psychiatric disorder for which novel and fast‐acting antidepressants are required. Targeted inhibition of the astrocytic inwardly rectifying potassium channel 4.1 (Kir4.1) in the lateral habenula could rapidly alleviate depression‐like behaviors. A pre...

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Hlavní autoři:	Sisi Wang, Xiaoyu Zhou, Mengdan Li, Chao Zhang, Haiyan Xu, Jingyi He, Li Zhan, Yueling Gu, Hao Gu, Tianyu Tu, Hanfang Liu, Taotao Lu, Yueming Zheng, Jian Li, Zhaobing Gao, Yixiang Xu
Médium:	Artigo
Jazyk:	Inglês
Vydáno:	Wiley 2026-02-01
Edice:	Advanced Science
Témata:	depression Kir4.1 inhibitors rapid‐onset (S)‐ketamine structural repurposing
On-line přístup:	https://doi.org/10.1002/advs.202509506
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