Discovery of a Novel and Potent Kir4.1 Inhibitor as a Safe and Rapid‐Onset Antidepressant Agent in Mice

Abstract Major depressive disorder is a serious psychiatric disorder for which novel and fast‐acting antidepressants are required. Targeted inhibition of the astrocytic inwardly rectifying potassium channel 4.1 (Kir4.1) in the lateral habenula could rapidly alleviate depression‐like behaviors. A pre...

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主要な著者:	Sisi Wang, Xiaoyu Zhou, Mengdan Li, Chao Zhang, Haiyan Xu, Jingyi He, Li Zhan, Yueling Gu, Hao Gu, Tianyu Tu, Hanfang Liu, Taotao Lu, Yueming Zheng, Jian Li, Zhaobing Gao, Yixiang Xu
フォーマット:	Artigo
言語:	Inglês
出版事項:	Wiley 2026-02-01
シリーズ:	Advanced Science
主題:	depression Kir4.1 inhibitors rapid‐onset (S)‐ketamine structural repurposing
オンライン･アクセス:	https://doi.org/10.1002/advs.202509506
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