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Discovery of a Novel and Potent Kir4.1 Inhibitor as a Safe and Rapid‐Onset Antidepressant Agent in Mice

Abstract Major depressive disorder is a serious psychiatric disorder for which novel and fast‐acting antidepressants are required. Targeted inhibition of the astrocytic inwardly rectifying potassium channel 4.1 (Kir4.1) in the lateral habenula could rapidly alleviate depression‐like behaviors. A pre...

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I tiakina i:
Ngā taipitopito rārangi puna kōrero
Ngā kaituhi matua: Sisi Wang, Xiaoyu Zhou, Mengdan Li, Chao Zhang, Haiyan Xu, Jingyi He, Li Zhan, Yueling Gu, Hao Gu, Tianyu Tu, Hanfang Liu, Taotao Lu, Yueming Zheng, Jian Li, Zhaobing Gao, Yixiang Xu
Hōputu: Artigo
Reo:Inglês
I whakaputaina: Wiley 2026-02-01
Rangatū:Advanced Science
Ngā marau:
Urunga tuihono:https://doi.org/10.1002/advs.202509506
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