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Functional exosome-mediated co-delivery of doxorubicin and hydrophobically modified microRNA 159 for triple-negative breast cancer therapy

Abstract Exosomes (Exo) hold great promise as endogenous nanocarriers that can deliver biological information between cells. However, Exo are limited in terms of their abilities to target specific recipient cell types. We developed a strategy to isolate Exo exhibiting increased binding to integrin α...

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Principais autores: Chunai Gong, Jing Tian, Zhuo Wang, Yuan Gao, Xin Wu, Xueying Ding, Lei Qiang, Guorui Li, Zhimin Han, Yongfang Yuan, Shen Gao
Formato: Artigo
Idioma:Inglês
Publicado em: BMC 2019-09-01
coleção:Journal of Nanobiotechnology
Assuntos:
Exosome
MicroRNA 159
Doxorubicin
Triple-negative breast cancer
Co-delivery
Acesso em linha:http://link.springer.com/article/10.1186/s12951-019-0526-7
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