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Myofibroblast-Derived Exosome Induce Cardiac Endothelial Cell Dysfunction

Background: Endothelial cells (ECs) play a critical role in the maintenance of vascular homeostasis and in heart function. It was shown that activated fibroblast-derived exosomes impair cardiomyocyte function in hypertrophic heart, but their effect on ECs is not yet clear. Thus, we hypothesized that...

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Principais autores: Prabhat Ranjan, Rajesh Kumari, Sumanta Kumar Goswami, Jing Li, Harish Pal, Zainab Suleiman, Zhongjian Cheng, Prasanna Krishnamurthy, Raj Kishore, Suresh Kumar Verma
Formato: Artigo
Idioma:Inglês
Publicado em: Frontiers Media S.A. 2021-04-01
coleção:Frontiers in Cardiovascular Medicine
Assuntos:
cardiac fibrosis
angiogenesis
microRNA
exosome (vesicle)
endothelial (dys)function
Acesso em linha:https://www.frontiersin.org/articles/10.3389/fcvm.2021.676267/full
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