The modulation of transcriptional expression and inhibition of multidrug resistance associated protein 4 (MRP4) by analgesics and their primary metabolites

During the course of a toxic challenge, changes in gene expression can manifest such as induction of metabolizing enzymes as a compensatory detoxification response. We currently report that a single 400 mg/kg acetaminophen (APAP) dose to C57BL/6J mice led to an increase in multidrug resistance-assoc...

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Hauptverfasser:	Renato J. Scialis, Carolina I. Ghanem, José E. Manautou
Format:	Artigo
Sprache:	Inglês
Veröffentlicht:	Elsevier 2020-06-01
Schriftenreihe:	Current Research in Toxicology
Schlagworte:	Acetaminophen Diclofenac Inhibition Metabolite MRP4
Online-Zugang:	http://www.sciencedirect.com/science/article/pii/S2666027X20300050
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