The genomic landscape of relapsed infant and childhood KMT2A-rearranged acute leukemia

Abstract To study the mechanisms of relapse in KMT2A-rearranged (KMT2A-r) acute lymphoblastic (ALL) and acute myeloid leukemia (AML), we performed whole-genome and exome sequencing of infants and children with relapsed ALL/AML (n = 36), and longitudinal deep-sequencing of 257 samples in 30 patients....

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Egile Nagusiak:	Louise Ahlgren, Mattias Pilheden, Helena Sturesson, Guangchun Song, Michael P. Walsh, Minjun Yang, Maud Maillard, Huanbin Zhao, Zhongshan Cheng, Varsha Singh, Anders Castor, Cornelis Jan Pronk, Hanne Vibeke Marquart, Birgitte Lausen, Pauline Schneider, Gisela Barbany, Katja Pokrovskaja Tamm, Jonas Abrahamsson, Olli Lohi, Linda Fogelstrand, Pablo Menendez, Rob Pieters, Jinghui Zhang, Karin Lindkvist-Petersson, Jun J. Yang, Tanja A. Gruber, Ronald W. Stam, Jing Ma, Anna K. Hagström-Andersson
Formatua:	Artigo
Hizkuntza:	Inglês
Argitaratua:	Nature Portfolio 2025-10-01
Saila:	Nature Communications
Sarrera elektronikoa:	https://doi.org/10.1038/s41467-025-64190-8
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