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Contrasting roles of KMT2C and KMT2D in breast cancer

Abstract KMT2C and KMT2D are paralogous lysine-methyltransferases that primarily monomethylate lysine residues at enhancer regions promoting an active transcriptional state. KMT2C and KMT2D are frequently mutated in multiple cancer types and in breast cancers mutations collectively occur at frequenc...

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Príomhchruthaitheoirí: Emily Tinsley, Philip Bredin, Sinead Toomey, Bryan T. Hennessy, Simon J. Furney
Formáid: Artigo
Teanga:Inglês
Foilsithe / Cruthaithe: Nature Portfolio 2025-10-01
Sraith:Scientific Reports
Rochtain ar líne:https://doi.org/10.1038/s41598-025-19027-1
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