Activating mutations remodel the chromatin accessibility landscape to drive distinct regulatory networks in KMT2A‐rearranged acute leukemia

Abstract Activating FLT3 and RAS mutations commonly occur in leukemia with KMT2A‐gene rearrangements (KMT2A‐r). However, how these mutations cooperate with the KMT2A‐r to remodel the epigenetic landscape is unknown. Using a retroviral acute myeloid leukemia (AML) mouse model driven by KMT2A::MLLT3,...

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Ngā kaituhi matua:	Qirui Zhang, Ton Falqués‐Costa, Mattias Pilheden, Helena Sturesson, Tina Ovlund, Vendela Rissler, Anders Castor, Hanne V. H. Marquart, Birgitte Lausen, Thoas Fioretos, Axel Hyrenius‐Wittsten, Anna K. Hagström‐Andersson
Hōputu:	Artigo
Reo:	Inglês
I whakaputaina:	Wiley 2024-09-01
Rangatū:	HemaSphere
Urunga tuihono:	https://doi.org/10.1002/hem3.70006
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