Understanding the characteristic behaviour of the wild-type and mutant structure of FLT3 protein by computational methods

FLT3 is a critical prognostic marker in acute myeloid leukemia (AML) due to its high frequency of mutation. Primary mutations in FLT3 include point mutations or deletions in the tyrosine kinase domain (TKD) and internal tandem duplications (ITD) in the juxtamembrane (JM) region. These mutations lead...

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Autors principals:	Saleena Younus, Özge Tatli, Ahmad Nasimian, Julhash U. Kazi, Lars Rönnstrand
Format:	Artigo
Idioma:	Inglês
Publicat:	Elsevier 2025-01-01
Col·lecció:	Computational and Structural Biotechnology Journal
Matèries:	Leukemia AML FLT3 protein Structural conformations Combination mutation Point mutation
Accés en línia:	http://www.sciencedirect.com/science/article/pii/S2001037025004246
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