Understanding the characteristic behaviour of the wild-type and mutant structure of FLT3 protein by computational methods

FLT3 is a critical prognostic marker in acute myeloid leukemia (AML) due to its high frequency of mutation. Primary mutations in FLT3 include point mutations or deletions in the tyrosine kinase domain (TKD) and internal tandem duplications (ITD) in the juxtamembrane (JM) region. These mutations lead...

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Главные авторы:	Saleena Younus, Özge Tatli, Ahmad Nasimian, Julhash U. Kazi, Lars Rönnstrand
Формат:	Artigo
Язык:	Inglês
Опубликовано:	Elsevier 2025-01-01
Серии:	Computational and Structural Biotechnology Journal
Предметы:	Leukemia AML FLT3 protein Structural conformations Combination mutation Point mutation
Online-ссылка:	http://www.sciencedirect.com/science/article/pii/S2001037025004246
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