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IFN-γ and TNF Induce Senescence and a Distinct Senescence-Associated Secretory Phenotype in Melanoma

Immune checkpoint blockade (ICB) therapy is a central pillar of melanoma treatment leading to durable response rates. Important mechanisms of action of ICB therapy include disinhibition of CD4<sup>+</sup> and CD8<sup>+</sup> T cells. Stimulated CD4<sup>+</sup> T helper 1 cells secrete the effector c...

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Gorde:
Xehetasun bibliografikoak
Egile Nagusiak: Lorenzo Homann, Maximilian Rentschler, Ellen Brenner, Katharina Böhm, Martin Röcken, Thomas Wieder
Formatua: Artigo
Hizkuntza:Inglês
Argitaratua: MDPI AG 2022-04-01
Saila:Cells
Gaiak:
Sarrera elektronikoa:https://www.mdpi.com/2073-4409/11/9/1514
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