A spatiotemporal atlas of senescence-associated secretory phenotype in fracture healing: stage-dependent mechanisms and therapeutic windows

Abstract Fracture repair remains a significant clinical challenge in orthopedics, particularly in aging populations. Accumulating evidence indicates that cellular senescence critically modulates the fracture microenvironment via the senescence-associated secretory phenotype (SASP). The SASP constitu...

Descripció completa

Dades bibliogràfiques

Autors principals:	Binyu Chen, Gan Li, Qihang Fang, Peng Ding, Youshui Gao
Format:	Artigo
Idioma:	Inglês
Publicat:	BMC 2026-03-01
Col·lecció:	Inflammation and Regeneration
Matèries:	Fracture healing Bone regeneration Cellular senescence Senescence-associated secretory phenotype (SASP) Spatiotemporal atlas Senolytics
Accés en línia:	https://doi.org/10.1186/s41232-026-00416-6
Etiquetes:	Afegir etiqueta Sense etiquetes, Sigues el primer a etiquetar aquest registre!