Prefusion RSV F Immunization Elicits Th2-Mediated Lung Pathology in Mice When Formulated With a Th2 (but Not a Th1/Th2-Balanced) Adjuvant Despite Complete Viral Protection

Respiratory syncytial virus (RSV) remains the most common cause of lower respiratory tract infections in children worldwide. Development of a vaccine has been hindered by the risk of developing enhanced respiratory disease (ERD) upon natural exposure to the virus. Generation of higher quality neutra...

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Principais autores:	Katherine M. Eichinger, Jessica L. Kosanovich, Sonal V. Gidwani, Aaron Zomback, Madeline A. Lipp, Timothy N. Perkins, Tim D. Oury, Nikolai Petrovsky, Christopher P. Marshall, Mark A. Yondola, Kerry M. Empey
Formato:	Artigo
Idioma:	Inglês
Publicado em:	Frontiers Media S.A. 2020-07-01
coleção:	Frontiers in Immunology
Assuntos:	RSV immunization prefusion infection Th1/Th2-immunity adjuvant
Acesso em linha:	https://www.frontiersin.org/article/10.3389/fimmu.2020.01673/full
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